联系电话:020-85280256  招生电话:020-85280255

张旭

博士,讲师,硕士生导师
研究方向:天然药物的开发与作用机制研究
电子邮箱:zhangxu@scau.edu.cn
     

个人简介



目前主要从事植物药用成分的研究,通过对植物中有效成分的提取分离以及结构修饰,在抗肿瘤、抗菌以及抗抑郁等方面对其药效以及作用机制进行深入探讨,进而开展进一步的药物研发工作。在医药、食品以及植物学领域SCI期刊发表论文10余篇,申请国家发明专利5项,承担省级项目1项。

承担主要科研项目:



1、黄梁木中抗肿瘤活性成分研究,华南农业大学青年项目,201609,主持(已结题);

2、高GABA-无咖啡因速溶茶的研发,广东省公益研究与能力建设项目,2017A020208048,主持(已结题)

代表性论文:



1、Jiahua Cui#, Xu Zhang#, Guang Huang#, Qijing Zhang, Jinyun Dong, Gege Sun, Qingqing Meng*, Shaoshun Li*. DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme, Molecular Pharmaceutics, 2019, 16 (1): 409-421.

2、Xu Zhang, Jiahua Cui, Qingqing Meng, Shaoshun Li, Wen Zhou*, Sui Xiao*. Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives, Mini-Reviews in Medicinal Chemistry, 2018, 18 (2): 164-172.

3、Chenkai Jiang, Zhen Zeng, Yahui Huang*,Xu Zhang*. Chemical compositions of Pu’er tea fermented by Eurotium Cristatum and their lipid-lowering activity, LWT-Food Science and Technology, 2018, 98: 204-211.

4、Jie Teng#, Wen Zhou#, Zhen Zeng, Wenfang Zhao, Yahui Huang*, Xu Zhang*. Quality components and antidepressant-like effects of GABA green tea, Food & Function, 2017, 8 (9): 3311-3318.

5、Dan Li, Yingyu Chen, Yahui Huang*, Lijuan Zhang, Jiagan Yang, Xingguo Xu, Qing Liu, Xu Zhang*. Study on the Anti-Tumor Ability of Niaowangzhong Green Tea, Journal of Food Biochemistry, 2017, 41 (1): e12305. 

6、Xu Zhang, Jiahua Cui, Wen Zhou, Shaoshun Li*. Design, synthesis and anticancer activity of shikonin and alkannin derivatives with different substituents on the naphthazarin scaffold, Chemical Research in Chinese Universities, 2015, 31 (3): 394-400.

7、Xu Zhang#, Rubing Wang#, Wen Zhou*, Sui Xiao, Qingqing Meng, Shaoshun Li*. Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome, AAPS PharmSciTech, 2015, 16 (2): 259-266.

8、Rubing Wang#, Xu Zhang#, Hualong Song, Shanshan Zhou, Shaoshun Li*. Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents, Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17): 4304-4307.

9、Wen Zhou#, Xu Zhang#, Ling Xiao, Jing Ding, Quanhua liu, Shaoshun Li*. Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives, European Journal of Medicinal Chemistry, 2011, 46 (8): 3420-3427.

奖励荣誉:



2017年黔南州科技进步一等奖


承担主要课程:



中药药理学、药事管理