个人简介

   张旭，中共党员，博士，副教授，硕士研究生导师。2006年湖南农业大学获学士学位，2009年湖南农业大学与中国农业科学院蔬菜花卉研究所联合培养获硕士学位，2015年上海交通大学获博士学位。2009-2010年湖南省农业科学院农产品加工研究所任实习研究员，2019-2021年波士顿大学医学院药理系从事博士后研究。目前主要从事中药资源开发与利用工作，包括特色药用植物资源的发掘、功能成分的药理作用及机制研究、药物以及药食同源产品的开发等。现任中国中医药教育协会中药及民族药研究与评价分会委员，广东省科技特派员，云浮市创新创业人才项目团队首席。

承担主要科研项目：

1. 广东省林业局绿美广东建设重点任务保障项目，广东省金毛狗脊的资源调查与迁地保护，2026/01-2026/12；

2. 湖南省烟草公司永州市公司科技项目，防治烟草主要叶斑病害的绿色纳米农药创制与应用，2025/09-2027/09；

3. 广东省百千万工程农村科技特派员团队重点派驻任务项目，“禅金”茶树新品种配套技术研究与示范，2024/10-2027/10；

4. 广东省林业局中央财政林业草原生态保护恢复项目，大叶茶、华南锥等国家重点保护野生植物的综合保护，2024/01-2024/12；

5. 云浮市2023年创业创新团队项目，特色茶树新品种培育创新团队，2023/05-2026/05；

6. 广东省林业局林业生态保护建设项目，南昆山毛叶茶种质资源的收集保存，2023/02-2023/12；

7. 广州市农村科技特派员专题项目，GABA茶加工技术示范推广，2023/04-2025/03；

8. 广东省科技厅公益研究与能力建设项目，高GABA-无咖啡因速溶茶的研发，2017/07-2020/05。

代表性论文：

1. Xiaomin Chen#, Yao Hu#, Zhen Zeng, Xu Zhang*, Yahui Huang*, Flavor quality and lipid-lowering function of mixed fermented Pu-erh tea with various monascus species, Foods, 2025, 14,1894（中科院二区，IF=5.1）

2. Xiaodan Qin#, Andrew Lam#, Xu Zhang#, Satyaki Sengupta, J. Bryan Lorgulescu, Hongru Ni, Sanjukta Das, Madison Rager, Zhenwei Zhou, Tao Zuo, Grace Meara, Alexander Floru, Chinyere Kemet, Divya Veerapaneni, Daniel Kashy, Liang Lin, Kenneth Lloyd, Lauren Kwok, Kaylee S. Smith, Raghavendar T. Nagaraju, Rob Meijers, Craig Ceol, Ching-Ti Liu, Sanda Alexandrescu, Catherine Wu, Derin Keskin, Rani George, Hui Feng*. CKLF instigates a “cold” microenvironment to promote MYCN-mediated tumor aggressiveness, Science Advances, 2024, 10 (11), eadh9547（中科院一区，IF=11.7）

3. Shiheng Chen#, Ziying Chen#, Dylan O’Neill Rothenberg, Yong Long, Huafeng Li, Xiaoyang Zeng, Zhen Zeng, Xiaoli Mo, Dunying Wu, Yinghong Liao, Yahui Huang*, Sui Xiao*, Xu Zhang*. Short-term steaming during processing impacts the quality of Citri Reticulatae ‘Chachi’ peel, Food Chemistry, 2024, 447, 138964（中科院一区，IF=9.8）

4. Mingxia Nie#, Jingyuan Huang#, Jiaoli Huang, Ziying Chen, Lazi Lin, Fulan Luo, Xu Zhang*, Sui Xiao*. Differences in the components of Neolamarckia cadamba from different provenance and the drug resistance reversal activity of characteristic alkaloid, Industrial Crops and Products, 2022, 186, 115145（中科院一区，IF=5.9）

5. Wenming Chen#, Cui Zhou#, Jiansheng Chen, Meizhu Wang, Fang Zhou, Chunmei Wang*, Xu Zhang*, Wen Zhou*. Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives, Bioorganic Chemistry, 2022, 119 (2022),105515（中科院一区，IF=5.1）

6. Sui Xiao#, Jingyuan Huang#, Yahui Huang, Huiqing Lai, Yi Zheng, Dahua Liang, Hang Xiao*, Xu Zhang*. Flavor Characteristics of Ganpu Tea Formed During the Sun-Drying Processing and Its Antidepressant-Like Effects, Frontiers in Nutrition, 2021, 119 (8), 647537（中科院二区，IF=6.59）

7. Peng Chen#, Shaobing Wang#, Chenyang Cao#, Wenchong Ye, Meizhu Wang, Cui Zhou, Wenmin Chen, Xu Zhang*, Keyu Zhang*, Wen Zhou^*. α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship, Bioorganic Chemistry, 2021, 116, 105295（中科院二区，IF=5.3）

8. Jiahua Cui#, Xu Zhang#, Guang Huang#, Qijing Zhang, Jinyun Dong, Gege Sun, Qingqing Meng*, Shaoshun Li*. DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme, Molecular Pharmaceutics, 2019, 16 (1): 409-421（中科院二区，IF=4.321）

9. Chenkai Jiang, Zhen Zeng, Yahui Huang*, Xu Zhang*. Chemical compositions of Pu’er tea fermented by Eurotium Cristatum and their lipid-lowering activity, LWT-Food Science and Technology, 2018, 98: 204-211（中科院二区，IF=3.714）

10. Xu Zhang, Jiahua Cui, Qingqing Meng, Shaoshun Li, Wen Zhou*, Sui Xiao*. Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives, Mini-Reviews in Medicinal Chemistry, 2018, 18 (2): 164-172（中科院三区，IF=2.842）

11. Jie Teng#, Wen Zhou#, Zhen Zeng, Wenfang Zhao, Yahui Huang*, Xu Zhang*. Quality components and antidepressant-like effects of GABA green tea, Food & Function, 2017, 8 (9): 3311-3318（中科院一区，IF=3.289）

12. Xu Zhang, Lifang Zhang, Chenyuan Cai, Feiqun Xue, Sui Xiao*. An Approach for Searching Bioactive Compounds from Traditional Chinese Plant Food and Herb Medicines by Investigating Spectrum-Effect Relationships, Current Pharmaceutical Analysis, 2017,13: 417-426（中科院四区，IF=0.859）

13. Xu Zhang#, Rubing Wang#, Wen Zhou*, Sui Xiao, Qingqing Meng, Shaoshun Li*. Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome, AAPS PharmSciTech, 2015, 16 (2): 259-266（中科院四区，IF=1.954）

14. Xu Zhang, Jiahua Cui, Wen Zhou, Shaoshun Li*. Design, synthesis and anticancer activity of shikonin and alkannin derivatives with different substituents on the naphthazarin scaffold, Chemical Research in Chinese Universities, 2015, 31 (3): 394-400（中科院四区，IF=1.086）

15. Rubing Wang#, Xu Zhang#, Hualong Song, Shanshan Zhou, Shaoshun Li*. Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents, Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17): 4304-4307（中科院三区，IF=2.420）

16. Wen Zhou#, Xu Zhang#, Ling Xiao, Jing Ding, Quanhua Liu, Shaoshun Li*. Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives, European Journal of Medicinal Chemistry, 2011, 46 (8): 3420-3427（中科院三区，IF=3.346）

出版著作：

1、《药理学与临床药物应用》，副主编，黑龙江科学技术出版社

承担主要课程：

中药药理学、药理学实验、药事管理学